If you switch between a desktop at home, a laptop on the train, and a workstation at a studio, installing Premiere on every machine is tedious. A portable version on a fast SSD lets you carry your workspace, presets, and projects.
Even though it is portable, Premiere Pro still requires substantial hardware to function properly. Running it from a slow USB drive will cause lag. Windows 10 or 11 (64-bit). adobe premiere pro portable 64 bits top