Older drivers are often more stable for legacy equipment.
Ensure you have the driver files (usually a folder containing ser2pl.inf , ser2pl64.inf , and .sys files) extracted to a folder on your desktop. Do not run the "Setup.exe" if it fails; manual installation is more reliable. prolific usb to serial comm port version 32 00 download 2021
There is a massive market of counterfeit Prolific chips (PL2303) used in generic USB-to-Serial cables. To combat this, Prolific updated their drivers (versions 3.4 and higher) to detect fake chips. If a fake chip is detected, the driver disables the port, causing it to stop working. Older drivers are often more stable for legacy equipment