: Errors like msvcr100.dll missing often require reinstalling the Microsoft Visual C++ Redistributable packages.

This usually happens if you’ve moved the game files from another drive or reinstalled Windows without a fresh installation of the game. Why Does PES 2010 Need a Registry Entry?

On 64-bit Windows, 32-bit applications like PES 2010 have their registry keys redirected to HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node . If the game only sees keys in the standard SOFTWARE\KONAMI path, it may fail to launch or update. Pro Evolution Soccer 2010 registry - RegFiles.net