No. The Remake was never released on PSP, and no ISO exists for it. PSP hardware cannot run it.

Here is the long answer—including what you can play, why those downloads are fake, and how to safely enjoy classic Resident Evil 2 on your Android or PC today.

PPSSPP is a fast and versatile PlayStation Portable emulator for Android, Windows, macOS, and iOS. It is the premier choice for running PSP ISOs at high resolutions, making older games look superior to their original hardware performance.